Thermo Fisher Scientific Tlk1 Polyclonal Antibody
Human Tlk1 단백질을 인식하는 rabbit polyclonal antibody로, WB, ELISA, IP에 적합합니다. Phosphorylated 및 non-phosphorylated 형태 모두 검출 가능하며, 고순도 affinity chromatography로 정제되었습니다. -20°C에서 보관 시 안정적입니다.
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Thermo Fisher Scientific Tlk1 Polyclonal Antibody
Applications & Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:10,000–1:50,000 |
| Immunoprecipitation (IP) | 1:200–1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Chimpanzee, Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to C-terminal region near amino acids 730–755 of human Tlk1 (isoform 1). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate (pH 7.2), 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot and freeze at -20°C or below for long-term storage.
- Avoid repeated freeze/thaw cycles.
- Centrifuge if solution is not clear after standing.
- Stable for several weeks at 4°C as undiluted liquid.
- Dilute only before immediate use.
This affinity purified antibody is directed against human Tlk-1 protein. It reacts with both phosphorylated and non-phosphorylated forms at the S743 residue (isoform 1).
The antibody will react with all isoforms of Tlk-1.
BLAST analysis suggests reactivity with human, chimpanzee, orangutan, and dog (100% homology).
Cross-reactivity with mouse, rat, and chicken may occur (93% homology).
Reactivity with other species has not been determined.
Target Information
TLK1 (Tousled-like kinase 1) is a nuclear serine/threonine kinase involved in chromatin assembly regulation.
Originally described in Arabidopsis, TLK1 is a target of the DNA damage checkpoint and is rapidly inactivated upon exposure to ionizing radiation.
Inactivation is mediated by the S-phase DNA damage checkpoint, requiring ATM, NBS, and CHK1.
Tousled-like kinases are nuclear serine/threonine kinases potentially involved in chromatin assembly regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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