Thermo Fisher Scientific Varicella zoster Virus ORF47 Polyclonal Antibody
Varicella zoster Virus ORF47 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 최적화된 고특이성 항체로, human 시료에 반응. PBS/glycerol buffer에 보관하며 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human KR2_VZVD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2691525 |
Target Information
The ORF47 gene encodes a multifunctional serine/threonine kinase involved in several processes, including:
- Egress of virus particles from the nucleus
- Modulation of the actin cytoskeleton
- Regulation of viral and cellular gene expression
It regulates nuclear localization of viral envelopment factor proteins 24 and 27 by phosphorylating the protein kinase ORF66, indicating its role in nuclear egress. ORF47 also disrupts host nuclear lamins (LMNA, LMNB1) and phosphorylates the viral Fc receptor composed of glycoproteins E (gE) and I (gI). Phosphorylation of gE by UL13 alters its subcellular localization from the host early endosome to the plasma membrane. ORF47 participates in transcriptional regulation of cellular and viral mRNAs mainly by phosphorylating the viral transcriptional regulator IE63.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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