Thermo Fisher Scientific Epstein Barr Virus BGLF4 Polyclonal Antibody

Thermo Fisher Scientific Epstein Barr Virus BGLF4 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution

• 1:1,000–1:3,000

Product Specifications

Product Specific Information

Predicted to react with Human samples.

Target Information

BGLF4 plays many key roles by phosphorylating several proteins including the viral DNA processivity factor BMRF1, EBNA1, and EBNA2. It modifies the host nuclear envelope structure and induces redistribution of nuclear envelope-associated proteins by phosphorylating host nucleoporins. This promotes nuclear transport of EBV lytic proteins and is required for efficient lytic DNA replication and release of nucleocapsids from the nucleus.
Additionally, BGLF4 contributes to host chromatin compaction during lytic replication, presumably by phosphorylating the host condensin complex and TOP2A. It induces disassembly of the nuclear lamina via phosphorylation of host LMNA, and phosphorylates substrates involved in capsid assembly and DNA packaging.
BGLF4 facilitates the switch from latent to lytic DNA replication by down-regulating EBNA1 replication function and phosphorylates the viral immediate-early protein BZLF1, inhibiting its sumoylation through interaction with host SUMO1 and SUMO2.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.