Thermo Fisher Scientific MAGE-1 (Target for Cancer Immunotherapy) Monoclonal Antibody (MA454)
MAGE-1 단백질을 표적으로 하는 암 면역치료 연구용 단클론 항체. 인간, 개, 쥐 시료에 반응하며 IHC(P) 및 IHC(PFA) 실험에 적합. Protein A/G로 정제된 액상형 항체로, 4°C 보관. 연구용으로만 사용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MA454 |
| Immunogen | Recombinant full-length human MAGE-A1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Human malignant neoplasms carry rejection antigens recognized by autologous, tumor-directed, and specific cytolytic CD8+ T lymphocyte clones (CTL). An important group of these antigens is encoded by the MAGE family of genes, identified as melanoma-associated antigens (MAAs).
MAGE-1 is expressed in a wide range of human neoplasms including melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, and renal cell carcinomas, but not in normal tissues.
Therefore, MAGE-1 may serve as a marker for early cancer detection and as a target for cancer immunotherapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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