Thermo Fisher Scientific MAGE-1 (Target for Cancer Immunotherapy) Monoclonal Antibody (MA454)
암 면역치료 타깃인 MAGE-1 단백질을 인식하는 Mouse IgG1 단클론 항체. 인간, 개, 흰쥐 반응성. IHC(P) 및 IHC(PFA) 적용 가능. 단백질 A/G 정제, PBS 버퍼, 무보존제. 연구용으로 암 조기 검출 및 면역치료 연구에 적합.
- 판매단위
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MA454 |
| Immunogen | Recombinant full-length human MAGE-A1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Human malignant neoplasms carry rejection antigens recognized by autologous, tumor-directed, cytolytic CD8+ T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes, identified as melanoma-associated antigens (MAAs).
MAGE-1 is expressed in a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) but not in normal tissues.
Therefore, the encoded antigen may serve as a marker for early detection and a target for cancer immunotherapy.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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