Thermo Fisher Scientific TPSG1 Monoclonal Antibody (279005)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In direct ELISAs, no cross-reactivity with recombinant mouse MCPT-1, recombinant human Tryptase alpha, rmTryptase beta-1, rhTryptase beta-2, or rmTryptase-5 is observed.
• Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

Tryptase gamma, also known as serine protease 31 or transmembrane tryptase, is an enzyme encoded by the TPSG1 gene in humans.
Tryptases are a family of trypsin-like serine proteases (peptidase family S1) and are enzymatically active only as heparin-stabilized tetramers. They are resistant to all known endogenous proteinase inhibitors.

Several tryptase genes are clustered on chromosome 16p13.3, including four functional genes: alpha I, beta I, beta II, and gamma I.
Beta I has an allelic variant alpha II, beta II has beta III, and gamma I has gamma II.
Beta tryptases are mainly expressed in mast cells, while alpha-tryptases predominate in basophils.

This gene differs from other members of the tryptase family by having a C-terminal hydrophobic domain that may serve as a membrane anchor.
Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.