Thermo Fisher Scientific TPSG1 Monoclonal Antibody (279005)
인간 TPSG1 단백질을 인식하는 Rat IgG2b 단클론 항체로 Western blot 및 Immunoprecipitation에 사용 가능. 재조합 인간 Tryptase gamma-1을 면역원으로 제작되었으며, 교차 반응 없음. Lyophilized 형태로 제공되며, -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunoprecipitation (IP) | 25 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 279005 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human Tryptase gamma-1/TPSG1 (Arg20–Arg281) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2577037 |
Product Specific Information
- In direct ELISAs, no cross-reactivity with recombinant mouse MCPT-1, recombinant human Tryptase alpha, rmTryptase beta-1, rhTryptase beta-2, or rmTryptase-5 is observed.
- Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Tryptase gamma, also known as serine protease 31 or transmembrane tryptase, is an enzyme encoded by the TPSG1 gene in humans.
Tryptases are a family of trypsin-like serine proteases (peptidase family S1) and are enzymatically active only as heparin-stabilized tetramers. They are resistant to all known endogenous proteinase inhibitors.
Several tryptase genes are clustered on chromosome 16p13.3, including four functional genes: alpha I, beta I, beta II, and gamma I.
Beta I has an allelic variant alpha II, beta II has beta III, and gamma I has gamma II.
Beta tryptases are mainly expressed in mast cells, while alpha-tryptases predominate in basophils.
This gene differs from other members of the tryptase family by having a C-terminal hydrophobic domain that may serve as a membrane anchor.
Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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