Thermo Fisher Scientific PSPN Monoclonal Antibody (275508)

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Immunohistochemistry (IHC)

8-25 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

275508

Immunogen

E. coli-derived recombinant human Persephin Ala61-Gly156 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PSPN,uniProtId:O60542-1,ncbiNodeId:9606,antigenRange:61-156,antigenLength:156,antigenImageFileName:MA5-23978_PSPN_O60542-1_House_mouse.svg,antigenImageFileNamePDP:MA5-23978_PSPN_O60542-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2610167

Product Specific Information

In Western blots, no cross-reactivity with recombinant human (rh) AgRP, rhArtemin, rh beta IG-H3, rhCripto-1, recombinant drosophila Decapentaplegic, rhGDNF, rhLAP, rhLatent TGF-beta 1, rhLefty-A, rhMIS, rhNeurturin, recombinant mouse (rh) Nodal, rmPersephin, rhTGF-alpha, rhTGF-beta 1, rhTGF-beta 1.2, rhTGF-beta 2, rhTGF-beta 3, or recombinant amphibian TGF-beta 5 is observed.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

Persephin is a disulfide-linked, homodimeric, neurotrophic factor structurally related to GDNF, artemin, and neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. The GFRalpha4 was first identified in chicken, and was later shown to be the preferential binding subunit for persephin. Persephin promotes the survival of ventral midbrain dopaminergic neurons and motor neurons after sciatic nerve oxotomy, and, like GDNF, promotes ureteric bud branching. However, in contrast to GDNF and neurturin, persephin does not support the survival of peripheral neurons.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.