Thermo Fisher Scientific HO-1 Monoclonal Antibody (6B8-2F2), FITC
HO-1 단백질을 인식하는 FITC 결합 단클론 항체로, Western blot 및 면역세포염색에 적합. 사람, 마우스, 랫트 반응성. 단일 클론 6B8-2F2, 단백질 G 정제. 4°C 암소 보관, 형광 특성 498/517nm.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6B8-2F2 |
| Immunogen | His-tagged Rat HO-1 |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 9.1 mM sodium bicarbonate/PBS with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931801 |
Additional Formats
- APC (Cat. No. MA5-45346)
- PerCP (Cat. No. MA5-45348)
- Custom conjugation available upon request
Product Specific Information
1 µg/mL of MA5-45347 was sufficient for detection of HO-1 in 10 µg of rat kidney lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 32 kDa. Does not cross-react with HO-2.
Target Information
Heme oxygenase (HO) is a microsomal enzyme that catalyzes the oxidation of heme to the antioxidant molecules biliverdin and carbon monoxide. HO consists of two homologous isozymes: inducible HO-1 and constitutively expressed HO-2.
HO-1 is induced by various stimuli, including oxidative stress, inflammatory agents, transforming growth factor beta, and heat shock. Increased HO-1 expression is considered a cellular defense mechanism against oxidative stress, as elevated HO can generate more bilirubin, an antioxidant.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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