Thermo Fisher Scientific CXCL10 (IP-10) Monoclonal Antibody (4NY8UN), PE, eBioscience
인간 CXCL10(IP-10)을 인식하는 4NY8UN 단클론 항체로, PE 형광 표지되어 있습니다. Flow Cytometry용으로 최적화되어 있으며, IFN-γ 유도 반응 및 T 세포 이동 연구에 적합합니다. 4°C 암소 보관, Affinity chromatography로 정제됨.
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Thermo Fisher Scientific CXCL10 (IP-10) Monoclonal Antibody (4NY8UN), PE, eBioscience
Applications
- Flow Cytometry (Intracellular staining)
Tested Dilution: 5 µL (0.125 µg)/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Recommended Isotype Control | Mouse IgG2b kappa Isotype Control (eBMG2b), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4NY8UN |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572728 |
Additional Formats
- Alexa Fluor 488
- Alexa Fluor 647
- PerCP-eFluor 710
- Custom conjugation available
Product Specific Information
This 4NY8UN monoclonal antibody reacts with human CXCL10 (Interferon Inducible Protein-10, IP-10), a CXC chemokine secreted by monocytes, epithelial cells, and endothelial cells in response to IFN-γ or other pro-inflammatory cytokines. CXCL10 binds to CXCR3 on activated T cells and plays a key role in Th1-type immune responses and T-cell migration. It also inhibits angiogenesis and tumor growth and modulates adhesion molecule expression. Elevated CXCL10 levels are associated with allergic inflammation, infections, and Alzheimer’s disease.
Applications Reported: Intracellular staining followed by flow cytometric analysis.
Applications Tested: Pre-titrated and validated using human peripheral blood cells and the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00).
Recommended usage: 5 µL (0.125 µg) per test (100 µL final volume; 10⁵–10⁸ cells/test).
Excitation: 488–561 nm
Emission: 578 nm
Compatible Lasers: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered
Target Information
IP-10 (Interferon-gamma induced protein 10 kD) belongs to the CXC chemokine superfamily and was first cloned in 1985. It stimulates monocyte, NK, and T-cell migration, regulates T-cell and bone marrow progenitor maturation, modulates adhesion molecule expression, and inhibits angiogenesis. IP-10 and Mig share the same receptor, CXCR3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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