Thermo Fisher Scientific CXCL10 (IP-10) Monoclonal Antibody (4NY8UN), PE, eBioscience

Thermo Fisher Scientific CXCL10 (IP-10) Monoclonal Antibody (4NY8UN), PE, eBioscience

Applications

• Flow Cytometry (Intracellular staining)

Tested Dilution: 5 µL (0.125 µg)/test

Product Specifications

Additional Formats

• Alexa Fluor 488
• Alexa Fluor 647
• PerCP-eFluor 710
• Custom conjugation available

Product Specific Information

This 4NY8UN monoclonal antibody reacts with human CXCL10 (Interferon Inducible Protein-10, IP-10), a CXC chemokine secreted by monocytes, epithelial cells, and endothelial cells in response to IFN-γ or other pro-inflammatory cytokines. CXCL10 binds to CXCR3 on activated T cells and plays a key role in Th1-type immune responses and T-cell migration. It also inhibits angiogenesis and tumor growth and modulates adhesion molecule expression. Elevated CXCL10 levels are associated with allergic inflammation, infections, and Alzheimer’s disease.

Applications Reported: Intracellular staining followed by flow cytometric analysis.
Applications Tested: Pre-titrated and validated using human peripheral blood cells and the Intracellular Fixation & Permeabilization Buffer Set (Product # 88-8824-00).
Recommended usage: 5 µL (0.125 µg) per test (100 µL final volume; 10⁵–10⁸ cells/test).

Excitation: 488–561 nm
Emission: 578 nm
Compatible Lasers: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered

Target Information

IP-10 (Interferon-gamma induced protein 10 kD) belongs to the CXC chemokine superfamily and was first cloned in 1985. It stimulates monocyte, NK, and T-cell migration, regulates T-cell and bone marrow progenitor maturation, modulates adhesion molecule expression, and inhibits angiogenesis. IP-10 and Mig share the same receptor, CXCR3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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