Thermo Fisher Scientific Factor X/Xa Polyclonal Antibody
Factor X/Xa에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 적합. Human 및 Mouse 반응성. 항원 친화 크로마토그래피로 정제되었으며, 고농도 액상 형태로 제공. 혈액응고 관련 연구에 이상적.
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Thermo Fisher Scientific Factor X/Xa Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 167–428 of Human Factor X |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546594 |
Product Specific Information
- Recommended positive controls: HeLa, human F10-transfected 293T cells, GL261, C8D30
- Predicted reactivity: Mouse (84%), Rabbit (81%), Rhesus Monkey (95%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Factor X undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by excision of the tripeptide RKR.
Two chains are held together by one or more disulfide bonds; the light chain contains two EGF-like domains, while the heavy chain contains the catalytic domain homologous to other hemostatic serine proteases.
The mature factor is activated by cleavage of the activation peptide by factor IXa (intrinsic pathway) or factor VIIa (extrinsic pathway).
The activated factor converts prothrombin to thrombin in the presence of factor Va, Ca²⁺, and phospholipid during blood clotting.
Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-29118_Factor_XXa_P00742-1_Rabbit.svg, PA5-29118_Factor_XXa_P00742-1_Rabbit_PDP.jpeg)
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