Thermo Fisher Scientific Cdc73 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: -

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, H1299, HepG2, Molt-4, Raji
• Predicted reactivity:
  • Mouse (100%)
  • Rat (99%)
  • Zebrafish (90%)
  • Xenopus laevis (91%)
  • Dog (100%)
  • Chicken (97%)
  • Rhesus Monkey (100%)
  • Bovine (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Cdc73 is a tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. It is part of the PAF1 complex, a five-subunit protein complex composed of Paf1, Cdc73, Leo1, Rtf1, and Ctr9. PAF1 was first purified from yeast in association with RNA polymerase II and is believed to function in transcription elongation. The yeast PAF (yPAF) complex interacts with RNA polymerase II and coordinates the setting of histone marks associated with active transcription. In addition to coordinating events during transcription (initiation, promoter clearance, and elongation), hPAF also coordinates events in RNA quality control. Cdc73 may also be involved in cell cycle progression through regulation of cyclin D1/PRAD1 expression.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.