Thermo Fisher Scientific TIMP-3 (Tissue Inhibitor of Metalloproteinase-3) Polyclonal Antibody
다양한 종에 반응하는 TIMP-3 폴리클로날 항체로, IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합. Protein A 정제 및 PBS 기반 버퍼로 안정화. 세포외기질 분해 효소 MMP 억제 연구용으로 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Bovine, Dog, Horse, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The amino acid sequence (aa175–211) used as the immunogen for TIMP3 Ab is 100% homologous in human, cow, dog, and horse, and 94% homologous in mouse and rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tissue inhibitor of metalloproteinase 3 (TIMP3) is a member of the tissue inhibitor of metalloproteinases gene family. It inhibits matrix metalloproteinases (MMPs) that degrade components of the extracellular matrix. TIMP3 is expressed upon mitogenic stimulation and binds irreversibly to zinc-dependent MMPs, inactivating them by binding to their catalytic zinc cofactor. Other functions include roles in nervous system development, tissue regeneration, and visual perception. In humans, the TIMP3 gene is located on chromosome 22.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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