Thermo Fisher Scientific TIMP2 (Tissue Inhibitor of Metalloproteinase 2) Recombinant Rabbit Monoclonal Antibody (TIMP2/8193R)
Recombinant rabbit monoclonal antibody targeting human TIMP2 protein. Validated for IHC on paraffin and PFA-fixed samples. High specificity and affinity for MMP-2 and MMP-9 related studies. Supplied as liquid form, 1 mg/mL, for research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | CHO cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | TIMP2/8193R |
| Immunogen | Recombinant fragment of human TIMP2 protein (UniProt ID: P16035-1, range: 1–220) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TIMP-1 and TIMP-2 are inhibitory enzymes of the matrix metalloproteinase family, important for maintaining connective tissue integrity.
TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (MMP-2 or gelatinase A), and also binds the active form of 92 kDa Type IV collagenase (MMP-9 or gelatinase B).
It inhibits the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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