Thermo Fisher Scientific CD171 Monoclonal Antibody (eBio5G3 (5G3)), APC, eBioscience
CD171(L1CAM)을 인식하는 eBio5G3(5G3) 단클론 항체로, APC 형광표지되어 유세포분석(Flow Cytometry)에 적합합니다. 인간 시료 반응성이 있으며, 신경세포 접착 및 종양세포 연구에 유용합니다. 4°C 보관, 동결 금지.
- 카탈로그번호
- 17-1719-41
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD171 Monoclonal Antibody (eBio5G3 (5G3)), APC, eBioscience
Applications
- Flow Cytometry (Flow): 5 µL (0.06 µg/test)
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2a |
| Recommended Isotype Control | Mouse IgG2a kappa Isotype Control (eBM2a), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio5G3 (5G3) |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% Sodium Azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573171 |
Additional Formats
Product Specific Information
The monoclonal antibody eBio5G3 recognizes CD171 (L1CAM), also known as neural cell adhesion molecule L1. CD171 is a member of the Ig superfamily containing six extracellular Ig domains and five fibronectin type III-like repeats. It functions as a cell adhesion molecule mediating homotypic and heterotypic cell–cell interactions in neuronal myelination, neurite outgrowth, and regeneration.
Expression of CD171 has been observed on monocytes, mature monocytic-derived and follicular dendritic cells, a minor subset of lymphocytes, neuronal tissue, and certain tumor cell lines. Expression on tumors is associated with tumor progression. The epitope of eBio5G3 is located in the amino-terminal Ig-like domain.
This antibody has been pre-titrated and validated by flow cytometric analysis using the tumor cell line Panc-1. Recommended use is 5 µL (0.06 µg) per test, defined as the amount of antibody sufficient to stain a cell sample in a final volume of 100 µL. Cell numbers may vary from 10⁵ to 10⁸ cells per test.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family. Its ectodomain, composed of multiple immunoglobulin-like and fibronectin type III-like repeats, is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This molecule plays a critical role in nervous system development, including neuronal migration and differentiation.
Mutations in the L1CAM gene cause several X-linked neurological syndromes collectively referred to as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia, and hydrocephalus). Alternative splicing of a neuron-specific exon contributes to functional diversity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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