Thermo Fisher Scientific PSMD1 Polyclonal Antibody
Thermo Fisher Scientific의 PSMD1 Polyclonal Antibody는 인간 단백질 PSMD1을 인식하는 rabbit IgG 항체로, WB, IHC, IP 등에 사용 가능합니다. 항원 친화 크로마토그래피로 정제되었으며, 4°C에서 보관합니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- A303851A
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of Human Proteasome (Prosome, Macropain) 26S Subunit, non-ATPase, 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan.
Target Information
Proteolytic degradation is essential for maintaining appropriate levels of short-lived and regulatory proteins involved in various cellular processes such as metabolism, stress response, antigen presentation, and cell cycle regulation.
The ubiquitin-proteasome pathway is the primary mechanism for protein degradation in the cytosol and nucleus of eukaryotic cells. The 26S proteasome is an ATP-dependent, multisubunit (~31) molecular complex (~2.5 MDa) composed of a 20S proteolytic core and one or two 19S regulatory subunits.
The 19S subunits recognize ubiquitinated proteins and facilitate their unfolding and translocation into the 20S core for degradation.
Defects in the ubiquitin-proteasome pathway are associated with several genetic diseases, including cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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