Thermo Fisher Scientific PSMC4 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, and Bovine

Target Information

The 26S proteasome is a multicatalytic proteinase complex composed of two major structures: a 20S core and a 19S regulator.

• The 20S core contains four rings of 28 non-identical subunits: two rings of seven alpha subunits and two rings of seven beta subunits.
• The 19S regulator includes a base (six ATPase and two non-ATPase subunits) and a lid (up to ten non-ATPase subunits).
  Proteasomes are widely distributed in eukaryotic cells and function in ATP/ubiquitin-dependent peptide cleavage within a non-lysosomal pathway.
  The immunoproteasome variant is essential for processing class I MHC peptides.
  The PSMC4 gene encodes one of the ATPase subunits, a member of the triple-A family with chaperone-like activity. This subunit interacts with nuclear hormone receptor family members and gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.