Thermo Fisher Scientific Phospho-RXRA (Ser260) Polyclonal Antibody
RXRA 단백질의 Ser260 인산화 형태를 특이적으로 인식하는 rabbit polyclonal 항체. Western blot 및 IHC(P)에서 검증됨. Human, Mouse, Rat 등 다양한 종에 반응. 고순도 정제 및 안정한 PBS/glycerol buffer로 보관 용이.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RXRA (Accession P19793), corresponding to amino acid residues around phosphorylated Ser260 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817341 |
Product Specific Information
This antibody detects endogenous levels of RXR alpha only when phosphorylated at Ser260.
Target Information
Retinoic Acid (RA), the active metabolite of vitamin A, regulates the transition of proliferating precursor cells (e.g., carcinoma and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptor (RXR) family—including RXR alpha, beta, and gamma—preferentially binds 9-cis-RA and regulates gene transcription by forming heterodimers with RA receptors. RAs may play therapeutic roles in cervical cancer and are known to be key regulators of neuronal development, synaptic plasticity, and learning and memory processes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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