Thermo Fisher Scientific Phospho-Trf2 (Thr188) Polyclonal Antibody
TRF2 단백질의 Thr188 인산화 형태를 특이적으로 인식하는 폴리클로날 항체. Western blot, IHC, ICC/IF에 사용 가능. 사람, 마우스, 랫트 반응성. PBS/glycerol 용액 형태로 제공되며 -20°C 보관. 연구용 전용 제품.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TERF2 (Accession Q15554), corresponding to amino acid residues around phosphorylated Thr188 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817336 |
Product Specific Information
This antibody detects endogenous levels of TRF2 only when phosphorylated at Thr188.
Target Information
TRF2 is a ubiquitously expressed protein involved in the control of telomere length. It contains a Myb-related DNA-binding motif and binds to duplex TTAGGG repeats, localizing to all human telomeres in metaphase chromosomes. TRF2 helps protect chromosome ends by maintaining telomere terminal structure and is implicated in preventing senescence in primary human cells. Inhibition of TRF2 has been shown to induce apoptosis in certain mammalian cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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