Thermo Fisher Scientific Cyclin T1 Polyclonal Antibody
Cyclin T1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며 인간, 마우스, 랫트 반응성. 고순도 항원 친화 크로마토그래피 정제, 액상 형태로 안정적 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CCNT1. Recombinant protein control fragment (Product #RP-102511). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789338 |
Product Specific Information
Immunogen sequence:
KTSEQTILNM ISQSSSDTTI AGLMSMSTST TSAVPSLPVS EESSSNLTSV EMLPGKRWLS SQPSFKLEPT QGHRTSENLA LTGVDHSLPQ DGSNAFISQK QNSKSVPSAK VSLKEYRAKH AEELAAQKRQ LEN
Target Information
This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9 and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, multiple forms of p-TEFb may include different cyclins with CDK9. The complex acts as a cofactor for HIV-1 Tat protein and is essential for full activation of viral transcription. Cyclin T1 and CDK9 also trigger transcript elongation via phosphorylation of RNA polymerase II’s C-terminal domain. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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