Thermo Fisher Scientific Phospho-Rb (Thr373) Polyclonal Antibody
인간 Retinoblastoma 단백질의 Thr373 인산화 부위를 인식하는 Rabbit Polyclonal 항체입니다. Western blot과 Immunocytochemistry에 사용 가능하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. -20°C에서 보관하며 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Phospho-Rb (Thr373) Polyclonal Antibody
Applications and Tested Dilutions
- Western Blot (WB): 1:1,000–1:3,000
- Immunocytochemistry (ICC/IF): 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Thr373 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903246 |
Target Information
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E.
Rb protein may act by regulating transcription, and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
Usage Notes
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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