Thermo Fisher Scientific SLC22A2 Monoclonal Antibody (640438)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 8–25 µg/mL

Flow Cytometry (Flow)

• Tested Dilution: 0.25 µg/10^6 cells

Product Specifications

Product Specific Information

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Target Information

Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from various tissues and function in the elimination of endogenous amines, cationic drugs, and other xenobiotics.
OCTs have a 12-transmembrane-domain structure and a large extracellular hydrophilic loop.

• OCT1: Primarily expressed in the liver
• OCT2 (SLC22A2): Expressed in kidney distal and proximal tubules; mediates pH-sensitive tubular uptake of organic compounds
• OCT3: Found in placenta, skeletal muscle, prostate, aorta, and liver
  An additional splice variant exists for OCT2, known as OCT2-A.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.