Thermo Fisher Scientific CD34 (Hematopoietic Stem Cell and Endothelial Marker) Monoclonal Antibody (CD34/7721)
인간 CD34 항원을 인식하는 단클론 항체로 조혈줄기세포 및 내피세포 마커 연구에 적합함. 파라핀 및 PFA 고정 조직에서 IHC에 사용 가능. 단클론 마우스 IgG 형태로, Protein A/G 정제 및 PBS 완충액에 보관. 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD34/7721 |
| Immunogen | Recombinant fragment (around aa100–300) of human HPCA1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD34 is a highly glycosylated monomeric surface protein (111–115 kDa) expressed on various stem cell populations. It serves as a stem cell marker, with reversible expression on human hematopoietic stem cells. CD34 may function as a receptor involved in endocytosis and regulation of adhesion, differentiation, and proliferation of hematopoietic progenitors.
CD34 possibly acts as an adhesion molecule facilitating stem cell attachment to the bone marrow extracellular matrix or stromal cells. It may also serve as a scaffold for glycans binding to lectins on stromal components and contribute to selectin-mediated interactions. The intracellular domain is phosphorylated by protein kinase C, indicating a potential role in signal transduction.
Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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배송/결제/교환/반품 안내
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