Thermo Fisher Scientific CD34 (Hematopoietic Stem Cell and Endothelial Marker) Monoclonal Antibody (ICO-115), PE
CD34 단일클론 항체(ICO-115), PE 형은 조혈줄기세포 및 내피세포 마커로 사용됩니다. 인간 및 랫트 반응성을 가지며, Flow Cytometry 및 Immunocytochemistry에 적합합니다. 단백질 A/G로 정제된 액상 항체로 4°C 암소 보관이 필요합니다.
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Thermo Fisher Scientific CD34 (Hematopoietic Stem Cell and Endothelial Marker) Monoclonal Antibody (ICO-115), PE
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| Flow Cytometry (Flow) | 5 µL / 10^6 cells |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ICO-115 |
| Immunogen | Blast cells of a chronic myeloid leukemia patient |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Wet ice |
Additional Formats
- Unconjugated
- CF 488
- CF 647
- Custom conjugation available upon request
Target Information
CD34 is a highly glycosylated monomeric surface protein (111–115 kDa) expressed on various stem cell populations. It serves as a stem cell marker, with reversible expression on human hematopoietic stem cells. CD34 may function as a receptor involved in adhesion, differentiation, and proliferation of hematopoietic stem cells and progenitors. It likely mediates attachment to bone marrow extracellular matrix or stromal cells and may act as a scaffold for glycan attachment, facilitating interactions with lectins. The intracellular domain is phosphorylated by activated protein kinase C, suggesting a role in signal transduction.
Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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