Thermo Fisher Scientific CD34 (Hematopoietic Stem Cell and Endothelial Marker) Monoclonal Antibody (rHPCA1/8500)
CD34 단백질을 표적으로 하는 인간 조혈줄기세포 및 내피세포 마커용 단일클론 항체. IHC(P) 및 IHC(PFA) 실험에 적합하며, 단백질 A/G 정제된 액상형 항체. PBS(pH 7.4) 버퍼에 보존제로 없이 제공되며, -20°C에서 보관 권장.
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- 947-MSM29-P1BX
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, lambda |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rHPCA1/8500 |
| Immunogen | Recombinant fragment (around aa100–300) of human HPCA1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD34 is a highly glycosylated monomeric surface protein (111–115 kDa) expressed on various stem cell populations. It serves as a stem cell marker, with reversible expression in human hematopoietic stem cells. CD34 may function as a receptor regulating adhesion, differentiation, and proliferation of hematopoietic and progenitor cells. It is also implicated in mediating stem cell attachment to the bone marrow extracellular matrix or stromal cells and may act as a scaffold for lineage-specific glycans, enabling binding to lectins expressed by stromal or marrow components. The intracellular domain of CD34 is phosphorylated by protein kinase C, suggesting a role in signal transduction. Dysregulation of CD34 is associated with diseases such as dermatofibrosarcoma and neurofibroma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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