Thermo Fisher Scientific FMR1 Monoclonal Antibody (2D4)
FMR1 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot과 ELISA에 적합. 인간 시료 반응성, 액상 형태, 보존제 무첨가. 연구용으로만 사용 가능하며 Fragile X Syndrome 관련 연구에 유용.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.1 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2D4 |
| Immunogen | FMR1 (NP_002015, 121–220 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ATKDTFHKIK LDVPEDLRQM CAKEAAHKDF KKAVGAFSVT YDPENYQLVI LSINEVTSKR AHMLIDMHFR SLRTKLSLIM RNEEASKQLE SSRQLASRFH
Target Information
FMR1 binds RNA and is associated with polysomes. The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm.
A trinucleotide repeat in the 5′ UTR is normally found at 6–53 copies, but an expansion to 55–230 repeats is the cause of fragile X syndrome.
Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure.
Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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