Thermo Fisher Scientific FLT4 Monoclonal Antibody (6B7)
FLT4 단클론 항체(6B7)는 인간 FLT4/VEGFR-3 단백질을 표적으로 하는 Mouse IgG1 항체로, Western blot과 ELISA에 적합합니다. 비결합형 액상 형태이며, PBS 버퍼에 보존제가 없습니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.3 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6B7 |
| Immunogen | FLT4 (NP_002011, 34 a.a. approximately 133 a.a) partial recombinant protein with GST tag (MW of GST tag alone: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
ITEESHVIDT GDSLSISCRG QHPLEWAWPG AQEAPATGDK DSEDTGVVRD CEGTDARPYC KVLLLHEVHA NDTGSYVCYY KYIKARIEGT TAASSYVFVR
Target Information
Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel development in embryos and angiogenesis in adult tissues.
Unlike VEGF, the related VEGFC stimulates the growth of lymphatic vessels through its specific lymphatic endothelial receptor VEGFR-3.
In 1998, Dumont showed that targeted inactivation of the VEGFR-3 gene in mice resulted in defective blood vessel development in early embryos.
Vasculogenesis and angiogenesis occurred, but large vessels became abnormally organized with defective lumens, leading to fluid accumulation in the pericardial cavity and cardiovascular failure at embryonic day 9.5.
Thus, VEGFR3 has an essential role in the development of the embryonic cardiovascular system before the emergence of the lymphatic vessels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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