Thermo Fisher Scientific IL-6 Receptor Monoclonal Antibody (B-R6)
인간 IL-6 수용체를 인식하는 Mouse IgG1 단클론 항체입니다. Western blot, IHC, Flow cytometry, ELISA 등 다양한 어플리케이션에 사용 가능합니다. IL-6 유도 세포 증식을 억제하는 생물학적 활성을 가집니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | 2 publications |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | - | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Flow Cytometry (Flow) | Assay-dependent | 2 publications |
| ELISA | Assay-dependent | 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
| Neutralization (Neu) | Assay-dependent | 2 publications |
| Miscellaneous PubMed (Misc) | - | 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | B-R6 |
| Immunogen | CHO cells transfected with cDNA corresponding to the gp80 IL-6 receptor gene |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 4.0 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2 |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| RRID | AB_2536348 |
Product Specific Information
- Specificity: Recognizes the Interleukin-6 Ra subunit (IL-6 Ra, IL-6 R), an 80 kDa protein
- Biological Activity: Inhibits IL-6 induced proliferation of XG-1 cells
Target Information
Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response.
The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases, and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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