Thermo Fisher Scientific AKR1C3 Recombinant Rabbit Monoclonal Antibody (ARC0857)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

ARC0857

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 200-300 of human AKR1C3 (P42330) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:AKR1C3,uniProtId:P42330-1,ncbiNodeId:9606,antigenRange:200-300,antigenLength:323,antigenImageFileName:MA5-35413_AKR1C3_P42330-1_Rabbit.svg,antigenImageFileNamePDP:MA5-35413_AKR1C3_P42330-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.47 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849314

Product Specific Information

Immunogen sequence: SKLLDFCKSK DIVLVAYSAL GSQRDKRWVD PNSPVLLEDP VLCALAKKHK RTPALIALRY QLQRGVVVLA KSYNEQRIRQ NVQVFEFQLT AEDMKAIDGL D

Target Information

AKR1C3 a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.