Thermo Fisher Scientific MYLK Recombinant Rabbit Monoclonal Antibody (ARC0842)
Recombinant rabbit monoclonal antibody targeting MYLK, validated for WB and ELISA. Recognizes human and rat MYLK. Produced in HEK293 cells, purified by affinity chromatography. Supplied as liquid in PBS with glycerol and BSA. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0842 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1800–1900 of human MYLK (Q15746) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.65 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849310 |
Product Specific Information
Immunogen sequence:
VAEEKPHVKP YFSKTIRDLE VVEGSAARFD CKIEGYPDPE VVWFKDDQSI RESRHFQIDY DEDGNCSLII SDVCGDDDAK YTCKAVNSLG EATCTAELIV E
Target Information
MYLK (MLCK) is a serine/threonine kinase that phosphorylates myosin regulatory light chains to facilitate myosin–actin interaction and contractile activity. It plays a key role in smooth muscle contraction, vascular permeability, and tissue edema formation.
In the nervous system, MLCK regulates astrocytic process growth and neurotransmitter release at sympathetic synapses. It also participates in fibroblast apoptosis signaling.
Smooth muscle and non-muscle isoforms are widely expressed in adult and fetal tissues, with non-muscle isoform 2 being predominant. The Telokin isoform binds calmodulin and is also broadly expressed. MLCK activity is likely down-regulated by phosphorylation and contains one fibronectin type III domain and nine immunoglobulin-like C2-type domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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