Thermo Fisher Scientific INPP5E Polyclonal Antibody
Thermo Fisher Scientific의 INPP5E Polyclonal Antibody는 인간 INPP5E 단백질을 인식하는 토끼 다클론 항체로, IHC(P)에서 1:50–1:200 희석 비율로 사용됩니다. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% 글리세롤, 0.02% sodium azide)에 보관됩니다. 연구용 전용 제품입니다.
- 카탈로그번호
- PA564248
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific INPP5E Polyclonal Antibody
Applications
Tested Application
- Immunohistochemistry (Paraffin) [IHC (P)]: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human INPP5E. Recombinant protein control fragment (Product #RP-103817) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642734 |
Product Specific Information
Immunogen sequence:
GKDTYDSTSK QRTPSYTDRV LYRSRHKGDI CPVSYSSCPG IKTSDHRPVY GLFRVKVRPG RDNIPLAAGK FDRELYLLGI KRRISKEIQR QQALQSQNSS TICSVS
Antigen sequence identity:
- Mouse: 90%
- Rat: 91%
Target Information
INPP5E (inositol polyphosphate 5-phosphatase), also known as phosphatidylinositol polyphosphate 5-phosphatase type IV, is a 644-amino-acid peripheral membrane protein associated with Golgi stacks. It belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type IV family and converts phosphatidylinositol-3,4,5-triphosphate (PtdIns 3,4,5-P3) to PtdIns-P2.
INPP5E is inactive toward water-soluble inositol phosphates and acts specifically on lipid substrates. It becomes phosphorylated upon DNA damage and is expressed in brain, heart, pancreas, testis, and spleen.
Defects in INPP5E are associated with Joubert syndrome type 1 (JBTS1), characterized by cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities, and psychomotor delay. Mutations may also cause MORMS (mental retardation-truncal obesity-retinal dystrophy-micropenis syndrome), an autosomal recessive disorder with moderate mental retardation, truncal obesity, congenital non-progressive retinal dystrophy, and micropenis in males.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.