Thermo Fisher Scientific INPP5E Polyclonal Antibody

Applications

Tested Application

• Immunohistochemistry (Paraffin) [IHC (P)]: 1:50–1:200

Product Specifications

Product Specific Information

Immunogen sequence:
GKDTYDSTSK QRTPSYTDRV LYRSRHKGDI CPVSYSSCPG IKTSDHRPVY GLFRVKVRPG RDNIPLAAGK FDRELYLLGI KRRISKEIQR QQALQSQNSS TICSVS

Antigen sequence identity:

• Mouse: 90%
• Rat: 91%

Target Information

INPP5E (inositol polyphosphate 5-phosphatase), also known as phosphatidylinositol polyphosphate 5-phosphatase type IV, is a 644-amino-acid peripheral membrane protein associated with Golgi stacks. It belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type IV family and converts phosphatidylinositol-3,4,5-triphosphate (PtdIns 3,4,5-P3) to PtdIns-P2.

INPP5E is inactive toward water-soluble inositol phosphates and acts specifically on lipid substrates. It becomes phosphorylated upon DNA damage and is expressed in brain, heart, pancreas, testis, and spleen.

Defects in INPP5E are associated with Joubert syndrome type 1 (JBTS1), characterized by cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities, and psychomotor delay. Mutations may also cause MORMS (mental retardation-truncal obesity-retinal dystrophy-micropenis syndrome), an autosomal recessive disorder with moderate mental retardation, truncal obesity, congenital non-progressive retinal dystrophy, and micropenis in males.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.