Thermo Fisher Scientific TIM3 Polyclonal Antibody
인간 TIM-3 단백질을 인식하는 Goat Polyclonal Antibody로, WB, IHC(P), Flow Cytometry에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 보존제 무첨가 PBS(5% 트레할로오스) 용액에 동결건조 형태로 제공됩니다. 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3–15 µg/mL |
| Flow Cytometry (Flow) | 0.25 µg per million cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human TIM-3 (Ser22–Arg200) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606421 |
Product Specific Information
- In direct ELISAs, approximately 5% cross-reactivity with recombinant mouse (rm) TIM-3 is observed.
- Less than 1% cross-reactivity with recombinant human TIM-1, rmTIM-1, and rmTIM-2 is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-domain containing-3) is a 281 amino acid, type I Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4⁺ Th1 and CD8⁺ Tc1 cells.
It consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved tyrosine phosphorylation motif in the cytoplasmic region.
TIM3 is involved in macrophage activation and autoimmune disease induction, down-regulates Th1-mediated immune responses, and contributes to immune tolerance.
It has been implicated in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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