Thermo Fisher Scientific LDLR Polyclonal Antibody
Thermo Fisher Scientific의 LDLR Polyclonal Antibody는 마우스 LDL 수용체를 인식하는 염소 유래 IgG 항체로, WB, IHC, ICC, Flow 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공되어 안정적인 보관이 가능합니다.
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- PA546987
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 5–15 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
| Flow Cytometry (Flow) | 2.5 µg per million cells | - |
| Neutralization (Neu) | Assay-Dependent | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse LDL R Ala22–Arg790 (Ala23Val, Cys27Gly) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608883 |
Product Specific Information
- In direct ELISAs, approximately 10% cross-reactivity with recombinant human LDL R is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL is normally bound at the cell membrane and taken into the cell, ending up in lysosomes where the protein is degraded and cholesterol is released. This process represses HMG CoA reductase, the rate-limiting enzyme in cholesterol synthesis, while stimulating cholesterol ester synthesis.
Mutations in the LDL-R gene cause familial hypercholesterolemia, an autosomal dominant disorder. LDL-R, along with SCARB1, CLDN1, and CD81, has been reported as an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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