Thermo Fisher Scientific IL1F9 Polyclonal Antibody
인간 IL-36γ/IL-1F9에 특이적인 Goat 폴리클로날 항체로, WB 및 Neutralization에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS와 trehalose로 보존. 염증 및 면역 반응 연구에 적합.
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Thermo Fisher Scientific IL1F9 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5 µg/mL |
| Neutralization (Neu) | 10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant human IL-36 gamma / IL-1F9 (Met1–Asp169) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2576888 |
Product Specific Information
- In direct ELISAs, cross-reactivity observed:
- ~15% with rhIL-1F6
- ~5% with rhIL-1F7
- <1% with rhIL-1α, rhIL-1β, rhIL-1F5, and rhIL-1F8
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level: <0.10 EU per 1 µg antibody (LAL method).
Target Information
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor, activating NF-kappa-B and MAPK pathways in target cells. Part of the IL-36 signaling system involved in epithelial barrier inflammation, similar to the IL-1 system. Plays a role in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T-cells to drive tissue infiltration, cell maturation, and proliferation. Induces expression of chemokines such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20, and CXCL1, as well as TNF-alpha, S100A7/psoriasin, and inducible NOS. May contribute to proinflammatory responses in neutrophilic airway inflammation and innate immune response to fungal pathogens like Aspergillus fumigatus.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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