Thermo Fisher Scientific CD155 Monoclonal Antibody (2H7CD155), PE, eBioscience

Thermo Fisher Scientific CD155 Monoclonal Antibody (2H7CD155), PE, eBioscience

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µL (2 µg)/test
Publications: View 4 publications

Product Specifications

Additional Formats

• APC
• FITC
• PE-Cyanine7
• PerCP-eFluor 710
• Super Bright 436
• Request custom conjugation

Product Specific Information

The monoclonal antibody 2H7CD155 recognizes CD155, also known as the poliovirus receptor. CD155 is a member of the Ig superfamily with four isoforms; only the alpha and delta forms are expressed on the membrane of monocytes, prostate cancer cells, and neurectodermal and monocytic tumor cell lines. It is also found during mid-gastrulation in embryonic development.
CD155 plays a role in adhesion via interaction with vitronectin and in NK cell-mediated tumor cell killing. Ligands include CD226 and CD96. Blocking CD155 is under therapeutic investigation for poliovirus variant prevention.

Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-titrated and tested by flow cytometry on normal human peripheral blood cells or human tumor cell line U937.
Use at 5 µL (2 µg) per test (final volume 100 µL). Cell number: 10⁵–10⁸ cells/test.

Excitation: 488–561 nm
Emission: 578 nm
Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered

Target Information

The CD155 gene encodes a transmembrane glycoprotein belonging to the immunoglobulin superfamily.
Its external domain mediates cell attachment to vitronectin, and the intracellular domain interacts with dynein light chain Tctex-1/DYNLT1.
This gene is specific to primates and acts as a cellular receptor for poliovirus during viral replication.
Multiple transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지