Thermo Fisher Scientific Ep-CAM/CD326 Recombinant Mouse Monoclonal Antibody (rEGP40, 1110)
Ep-CAM/CD326 단백질을 표적으로 하는 재조합 마우스 단클론 항체로, IHC(P) 및 Peptide Array에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며 HEK293 세포에서 발현되었습니다. 단백질 A/G로 정제된 액상 항체로, 4°C에서 보관합니다.
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- 4072-MSM23-P0
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rEGP40, 1110 |
| Immunogen | Recombinant human EpCAM fragment from the cytoplasmic domain (around aa 289–314) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- For formalin-fixed tissues, heat tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Ep-CAM (epithelial adhesion molecule, also known as ESA) is a transmembrane glycoprotein (~40 kDa) expressed in epithelial tissues. It functions as a calcium-independent cell adhesion molecule influencing cell cycle, proliferation, and metabolism via induction of c-myc and cyclins A and E.
Ep-CAM-mediated adhesions negatively regulate cadherin-based adhesions, affecting epithelial differentiation and growth. Overexpression is associated with increased epithelial proliferation and is commonly observed in human carcinomas.
Ep-CAM serves as a marker for tumors of epithelial lineage and is expressed on the basolateral surface of most simple epithelia and many carcinoma types. It can also distinguish adenocarcinomas from pleural mesotheliomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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