Thermo Fisher Scientific PDCD1/PD1/CD279 (Programmed Cell Death 1) Recombinant Rabbit Monoclonal Antibody (PDCD1/8170R)

Applications

Immunohistochemistry (PFA fixed) (IHC (PFA))

• Tested Dilution: 1–2 µg/mL

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from APC.
PD-1 binds two related ligands, PDL-1 and PDL-2. Upon binding, PD-1 signaling inhibits immune activation in the absence of danger signals like LPS or other pathogen-associated molecules.
PD1-deficient mice exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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