Thermo Fisher Scientific GPR32 Polyclonal Antibody
Thermo Fisher Scientific의 GPR32 Polyclonal Antibody는 인간 GPR32 단백질을 검출하는 토끼 IgG 폴리클로날 항체입니다. WB 및 IHC(P) 실험에 적합하며, glycosylated receptor 검출에 유용합니다. 연구용으로만 사용되며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:3,000 | View publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Cat, Hamster, Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated Cys-LARAFGEEEFLSS-Abu-PRGNAPRE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2540487 |
Product Specific Information
- IHC (P) analysis shows positive staining of GPR32 in human small intestine tissue neuroendocrine cells.
- WB analysis shows GPR32 in glycoprotein-enriched fractions from GPR32 overexpressing 293 cells.
- Additional unknown bands at ~30kD and ~130kD were also detected.
- Theoretical MW of GPR32 is ~40kD, but observed band runs at ~60kD due to glycosylation.
Target Information
The G-protein-coupled receptor (GPCR) superfamily includes approximately 600–1,000 members, representing the largest known class of molecular targets with proven therapeutic value.
The intronless GPR32 gene encodes an orphan G protein-coupled receptor that binds to resolvin D1 and lipoxin A4.
Resolvin D1 binding to GPR32 is associated with:
- Resolution of pulmonary inflammation
- Suppression of TGFβ-induced epithelial mesenchymal transition in A549 lung cancer cells
Resolvins are being evaluated as new drug candidates acting at the resolution phase of chronic inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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