Thermo Fisher Scientific KCNJ5 Polyclonal Antibody
KCNJ5 단백항체로 인간, 마우스, 랫트 반응성 보유. Western blot, ELISA, Immunoprecipitation에 적합. 합성 펩타이드 기반 면역원 사용. 액상 형태, 친화 크로마토그래피로 정제. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 1:50–1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 350–450 on human GIRK4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
G protein-coupled inwardly rectifying potassium channels (Kir3.1 through Kir3.4) are associated with numerous neurotransmitter receptors in the brain and are abundantly expressed in regions such as the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex, and thalamus. Also known as GIRK, Kir3 potassium channels localize to soma, dendrites, and axons of neurons. Gβγ subunits from G protein heterotrimers bind to and regulate Kir3 channel activity. Gβ3- and Gβ4-containing dimers enhance K⁺ current, while Gβ5-containing dimers inhibit it. Kir3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which phosphorylates Kir3 tyrosine residues, effectively inactivating the channels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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