Thermo Fisher Scientific KChIP3 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1–3 µg/mL

Product Specifications

Product Specific Information

This antibody is expected to recognize isoform 1 (NP_038462.1) only.
Tested in Peptide ELISA: antibody detection limit dilution 1:1,000.

Target Information

Voltage-gated potassium (Kv) channels are key components of potassium currents in the heart and central nervous system.

• In the heart, Kv4 channels are involved in the repolarization phase of the action potential.
• In the brain, these channels prevent reverse-propagation of action potentials.

Associated with Kv4 channels are calcium-binding proteins termed KChIPs (Kv channel interacting proteins).
KChIPs bind to the cytoplasmic amino termini of Kv4 alpha-subunits and modulate channel function.

Known KChIPs include:

1. KChIP1 – expressed in the brain
2. KChIP2 – expressed in brain, heart, and lung (isoforms a, b, c)
3. KChIP3 – also known as calsenilin or DREAM, expressed in brain and testis

KChIP3 not only modulates Kv4 currents but also functions as a DNA-binding transcriptional regulator by binding to DRE and repressing transcription from the early-response gene c-fos.
It is also associated with presenilins and implicated in beta-amyloid formation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.