
Thermo Fisher Scientific GATA-3 (Breast and Urothelial Marker) Monoclonal Antibody (rGATA3/3870)
GATA-3 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체로, 유방암 및 요로상피암 마커 연구에 적합함. Western blot과 면역조직화학(IHC)에 사용 가능하며, 인간과 랫트 반응성. 고순도 Protein A/G 정제, 액상 형태로 4°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rGATA3/3870 |
| Immunogen | Recombinant full-length human GATA-3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes.
GATA3 is an enhancer-binding protein containing a zinc finger domain, abundantly expressed in the T-lymphocyte lineage, and participates in T-cell receptor gene activation through enhancer binding.
Labastie et al. (1994) cloned the human gene comprising six exons distributed over 17 kb of DNA. Its two zinc fingers are encoded by separate exons highly conserved with those of GATA1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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