Thermo Fisher Scientific GATA-3 (Breast and Urothelial Marker) Monoclonal Antibody (GATA3/2441)
GATA-3 단백질을 표적하는 Mouse 모노클로날 항체로, 유방 및 요로상피 암 마커 연구에 적합. Western blot, Flow cytometry, ELISA, Peptide array 등 다양한 응용 가능. 고순도 Protein A/G 정제, 4°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 1–2 µg/10^6 cells
ELISA
- Tested Dilution: Assay-dependent
Peptide Array
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GATA3/2441 |
| Immunogen | Recombinant fragment of human GATA3 protein (around aa 357–436) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The genes for all four subunits of the T-cell antigen receptor (alpha, beta, gamma, and delta) are controlled by distinct enhancers and their enhancer-binding proteins. Marine and Winoto (1991) identified a common TCR regulatory element by demonstrating binding of the enhancer-binding protein GATA3 to the enhancer elements of all four TCR genes.
GATA3, containing a zinc finger domain, is abundantly expressed in the T-lymphocyte lineage and participates in T-cell receptor gene activation through enhancer binding. Labastie et al. (1994) cloned the human gene, which comprises six exons distributed over 17 kb of DNA. Its two zinc fingers are encoded by two separate exons highly conserved with those of GATA1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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