Thermo Fisher Scientific ROR1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Flow Cytometry (Flow)

• Tested Dilution: 1:10–1:50

Product Specifications

Target Information

Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated surface protein predominantly expressed during embryogenesis, where it plays roles in organ morphogenesis, nervous system development, and maintenance of neural progenitor cells. It is virtually absent from normal pediatric and adult tissues except for low-level expression in immature B cell precursors (hematogones) and adipocytes. ROR1 is notably overexpressed in several B lymphoid and epithelial malignancies, including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, and lung adenocarcinoma.

Initially identified during PCR-based cloning of human neuroblastoma cells, ROR1 was classified as an orphan receptor due to the absence of a known ligand. Wnt-5a has since been suggested as a candidate ligand, with ROR1 functioning as a pseudokinase that promotes proliferation and apoptosis resistance in cancer cells through interactions with Wnt-5a and TCL1-mediated AKT co-activation. ROR1 is expressed as a glycoprotein containing extracellular immunoglobulin-like, Frizzled, and Kringle domains, as well as an intracellular tyrosine kinase domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.