Thermo Fisher Scientific ROR1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Receptor-tyrosine-kinase-like orphan receptor 1 (ROR1) is a tumor-associated surface protein predominantly expressed during embryogenesis, involved in organ morphogenesis, nervous system development, and neural progenitor cell maintenance and survival. It is virtually absent from normal pediatric and adult tissues except for low-level expression in immature B cell precursors (hematogones) and adipocytes.

ROR1 is notably overexpressed and considered a survival factor in several malignancies including chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL), marginal zone lymphoma, and lung adenocarcinoma. Initially identified during PCR-based cloning of a human neuroblastoma cell line, ROR1 was categorized as an orphan receptor due to its unknown ligand. Wnt-5a has since been suggested as a candidate ligand, with ROR1 functioning as a pseudokinase promoting proliferation and resistance to apoptosis in cancer cells through Wnt-5a interaction and TCL1 co-activation of AKT.

ROR1 is expressed as a glycoprotein containing extracellular immunoglobulin-like, Frizzled, and Kringle domains, and an intracellular tyrosine kinase domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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