Thermo Fisher Scientific TNFS15/VEGI (Vascular Endothelial Growth Inhibitor) Monoclonal Antibody (VEGI/1283)
VEGI/1283 단클론 항체로 인간 VEGI 단백질을 특이적으로 인식. IHC(P), IHC(PFA) 등 다양한 면역염색에 사용 가능. 혈관내피세포 성장 억제 연구 및 TNF 관련 신호전달 연구에 적합. 단백질 A/G 정제, 보존제 없음.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VEGI/1283 |
| Immunogen | Recombinant human VEGI fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It is abundantly expressed in endothelial cells but not in B or T cells. Expression is inducible by TNF and IL-1α. This cytokine binds to receptors TNFRSF25 and TNFRSF21/DR6, activating NF-κB and MAP kinases, and acts as an autocrine factor inducing apoptosis in endothelial cells. It inhibits endothelial cell proliferation and may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported, though its sequence is undetermined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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