Thermo Fisher Scientific CD48 Monoclonal Antibody (MEM-102)
CD48 단백질을 인식하는 Mouse IgG1 단클론 항체로, 인간 및 영장류 시료에 반응합니다. Western blot, IHC, Flow cytometry, IP 등에 사용 가능하며, Protein A로 정제된 액상형 제품입니다. PBS buffer에 보관하며 4°C에서 냉장 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–10 µg/mL |
| Flow Cytometry (Flow) | 2 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-102 |
| Immunogen | Burkitt’s lymphoma cell line Raji |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1072498 |
Available Conjugated Formats
Product Specific Information
This antibody reacts with CD48 (Blast-1), a 40–47 kDa GPI-anchored extracellular membrane protein belonging to the immunoglobulin supergene family. CD48 is widely expressed on hematopoietic cells but is negative on granulocytes, platelets, and erythrocytes.
Target Information
CD48 (Blast-1) is part of the CD2 subset of the Ig superfamily, including CD2, CD58, CD84, CD150, CD229, and CD244. These molecules mediate homotypic or heterotypic adhesion by binding to other Ig family members. CD48 serves as a high-affinity ligand for 2B4 and a low-affinity ligand for CD2, playing roles in NK and NK-T cell proliferation and eosinophil activation. CD48 expression increases in several infectious diseases and is a marker for detecting GPI anchoring defects in paroxysmal nocturnal hemoglobinuria (PNH). The 2B4–CD48 interaction may also be involved in allergic airway diseases and could serve as a pharmacological target for allergic rhinitis and asthma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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