Thermo Fisher Scientific CD48 Monoclonal Antibody (MEM-102)

Applications and Tested Dilution

Product Specifications

Available Conjugated Formats

• APC
• Biotin
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody reacts with CD48 (Blast-1), a 40–47 kDa GPI-anchored extracellular membrane protein belonging to the immunoglobulin supergene family. CD48 is widely expressed on hematopoietic cells but is negative on granulocytes, platelets, and erythrocytes.

Target Information

CD48 (Blast-1) is part of the CD2 subset of the Ig superfamily, including CD2, CD58, CD84, CD150, CD229, and CD244. These molecules mediate homotypic or heterotypic adhesion by binding to other Ig family members. CD48 serves as a high-affinity ligand for 2B4 and a low-affinity ligand for CD2, playing roles in NK and NK-T cell proliferation and eosinophil activation. CD48 expression increases in several infectious diseases and is a marker for detecting GPI anchoring defects in paroxysmal nocturnal hemoglobinuria (PNH). The 2B4–CD48 interaction may also be involved in allergic airway diseases and could serve as a pharmacological target for allergic rhinitis and asthma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.