Thermo Fisher Scientific uPAR Polyclonal Antibody
Human uPAR(CD87)을 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, IHC-P에 사용 가능. KLH-conjugated synthetic peptide(aa 136–166)로 면역화. 2 mg/mL 농도의 액상 제품으로 PBS(pH 7.4)에 sodium azide 포함. 4°C 단기, -20°C 장기 보관 권장.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between amino acids 136–166 from the central region of human PLAUR (uPAR, CD87; UniProt ID: Q03405-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Size-exclusion chromatography, Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2165465 |
Product Specific Information
This antibody is predicted to react with non-human primate based on sequence homology.
Target Information
The urokinase-type plasminogen activator receptor (uPAR, also known as PLAUR or CD87) is a key molecule regulating cell-surface plasminogen activation. It plays important roles in both normal physiological and pathological processes.
The human PLAUR cDNA encodes 335 amino acids, including a predicted 22-residue signal peptide and a hydrophobic C-terminal region. It produces a highly glycosylated ~50 kDa protein in monocytes, anchored to the plasma membrane via a glycosyl-phosphatidylinositol (GPI) linkage.
uPAR interacts with the carbohydrate-binding domain of SELL in neutrophil membranes, similar to its association with β2 integrins. PLAUR-mediated calcium mobilization is SELL-dependent.
Increased uPAR mRNA levels correlate with the invasive potential and clinical stage of endometrial carcinomas, showing a 33-fold increase in advanced tumors compared to normal tissue. uPAR protein expression also correlates with recurrence and mortality rates, making it a potential prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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