Thermo Fisher Scientific Phospho-p70 S6 Kinase (Ser371) Polyclonal Antibody
p70 S6 Kinase의 Ser371 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(P) 검증 완료. 세포 성장, 단백질 합성 조절 연구에 적합. 액상 형태, -20°C 보관, 1 mg/mL 농도.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Published species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human p70 S6 Kinase around the phosphorylation site of Ser371 (V-D-SP-P-D) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2554908 |
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with two non-identical kinase catalytic domains that phosphorylates several residues of the S6 ribosomal protein. p70 S6 kinase is predominantly localized in the cytoplasm and is essential in growth factor-regulated cell proliferation, cell motility pathways (such as metastasis), immune response, and tissue repair. It acts downstream of phosphoinositide (PI) 3-kinase, with its main physiological target being the S6 ribosomal protein, which regulates protein synthesis. The kinase activity of p70 S6 kinase promotes protein synthesis and cell proliferation. Amplification or overexpression of p70 S6 kinase has been observed in certain breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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