Thermo Fisher Scientific Phospho-p70 S6 Kinase (Ser418) Polyclonal Antibody
Phospho-p70 S6 Kinase (Ser418)에 특이적인 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 적용 가능. 세포 성장 및 단백질 합성 관련 연구에 유용하며, 고순도 액상 형태로 제공. -20°C 보관, Wet ice 배송.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human P70S6K around the phosphorylation site of Ser418 (I-G-SP-P-R) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554909 |
Target Information
RPS6KB1 (p70S6K) is a serine/threonine kinase with two non-identical kinase catalytic domains that phosphorylates several residues of the S6 ribosomal protein. p70 S6 kinase is predominantly localized in the cytoplasm and is essential in growth factor–regulated cell proliferation, pathways involving cell motility (such as metastasis), immune response, and tissue repair. It acts downstream of phosphoinositide (PI) 3-kinase, targeting the S6 ribosomal protein to upregulate protein synthesis. Amplification and overexpression of p70 S6 kinase are observed in certain breast cancer cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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