ELK Biotechnology AMPKα2 rabbit pAb
AMPKα2 rabbit pAb는 AMPK의 α2 촉매 서브유닛을 인식하는 폴리클로날 항체입니다. WB에 적합하며, 세포 내 에너지 항상성 연구에 활용됩니다. Human, Mouse, Rat에 반응하며, -20°C에서 1년간 보관 가능합니다.
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AMPKα2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | AMPKα2 rabbit pAb |
| Alternative Names | PRKAA2; AMPK; AMPK2; 5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase |
| Applications | WB |
| Recommended Dilutions | WB: 1:1000–2000 |
| Immunogen | Recombinant Protein of AMPKα2 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Observed Band | 62 kD |
| Gene ID (Human) | 5563 |
| Human Swiss-Prot No | P54646 |
| Cellular Localization | Cytoplasm, Nucleus. In response to stress, recruited by p53/TP53 to specific promoters. |
| Species Reactivity | Human, Mouse, Rat |
Background
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit and non-catalytic beta and gamma subunits. It functions as a key energy-sensing enzyme that monitors cellular energy status. Upon metabolic stress, AMPK is activated and phosphorylates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), which are crucial for fatty acid and cholesterol biosynthesis. Studies in mice suggest this subunit regulates whole-body insulin sensitivity and maintains myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]
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