ELK Biotechnology Prealbumin rabbit pAb

제품명

Prealbumin rabbit pAb

제품 개요

Prealbumin(Transthyretin, ATTR, TBPA)은 갑상선 호르몬과 레티놀(비타민 A)을 운반하는 단백질입니다. 본 항체는 인간 Prealbumin의 81–130 아미노산 서열에서 합성된 펩타이드를 면역원으로 제작된 토끼 폴리클로날 항체입니다. WB 및 IHC 분석에 적합합니다.

제품 사양

Background

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin, and orosomucoid. Transthyretin is a carrier protein that transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. Diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome.